Inoculum size, immune responses, and the nonlinear host-virus interactions

Friday, February 14, 2020 - 2:00pm to 3:15pm
WXLR 113


Stanca Ciupe
Department of Mathematics
Virginia Tech


Experimental studies have shown that immune protection and disease severity do not correlate linearly with the size and infectious-stage of viral inoculum. We use mathematical models in connection with data to better represent the relationship between the inoculum dose and disease outcome. In this talk, I will present two case studies: simian immunodeficiency virus infection in rhesus macaques and hepatitis B virus infection in non-human primates to provide hypotheses on when different inoculum doses trigger immune responses that provide protection, induce immune tolerance and chronic disease, and/or lead to pathogenesis.  Such results can guide our understanding of the virus-host dynamics that control virus infections or permit a transition to chronic disease.