Inoculum size, immune responses, and the nonlinear host-virus interactions

Friday, February 14, 2020 - 2:00pm to 3:15pm
Location: 
WXLR 113

Speaker

Stanca Ciupe
Professor
Department of Mathematics
Virginia Tech

Abstract

Experimental studies have shown that immune protection and disease severity do not correlate linearly with the size and infectious-stage of viral inoculum. We use mathematical models in connection with data to better represent the relationship between the inoculum dose and disease outcome. In this talk, I will present two case studies: simian immunodeficiency virus infection in rhesus macaques and hepatitis B virus infection in non-human primates to provide hypotheses on when different inoculum doses trigger immune responses that provide protection, induce immune tolerance and chronic disease, and/or lead to pathogenesis.  Such results can guide our understanding of the virus-host dynamics that control virus infections or permit a transition to chronic disease.

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